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Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err to the side of caution and allow the FDA do its job and demand some research be done in order that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on his or her medications. Researchers found that participants taking this drug for any year, lost excess weight within 4 weeks and have kept the weight off throughout the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, which can make them far better and safer. Combo-pilling is the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular could be the fact that as of right now there are no long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise hypertension and pulse rate, and mustn't be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not be used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. Other people who should avoid using Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave really should not be prescribed for girls who are pregnant or trying to become pregnant.